depopulate

Short definition from Wiktionary

Verb

1. 1
   To reduce the population of a region by disease, war, forced relocation etc.
2. 2
   To remove the components from a circuit board.
3. 3
   To become depopulated, to lose its population.

Adjective

1. 1
   Depopulated (sense 1).
2. 2
   Barren, devoid of inhabitants; utterly destroyed, devastated .