derange

Short definition from Wiktionary

Verb

1. 1
   To cause (someone) to go insane or become deranged.
2. 2
   To cause disorder in (something); to distort from its ideal state.
3. 3
   To cause to malfunction or become inoperative.
4. 4
   To disrupt (somebody's) plans, to inconvenience; to derail.