exhaustion

Short definition from Wiktionary

Noun

1. 1
   The point of complete depletion, of the state of being used up.
2. 2
   Supreme tiredness; having exhausted energy.
3. 3
   The removal (by percolation etc) of an active medicinal constituent from plant material.
4. 4
   The removal of all air from a vessel (the creation of a vacuum).
5. 5
   An exhaustive procedure