screw up

Short definition from Wiktionary

Verb

1. 1
   To tighten or secure with screws.
2. 2
   To raise (rent, fees, etc.) to extortionate levels.
3. 3
   To raise or summon up.
4. 4
   To twist into a contorted state.
5. 5
   To squint.
6. 6
   To make a mess of; to ruin.
7. 7
   To blunder; to make a mistake.

Noun

1. 1
   Alternative spelling of screwup.